Renal and intestinal hexose transport in familial glucose-galactose malabsorption

Renal and intestinal hexose transport in familial glucose-galactose malabsorption.

Glucose transport by jejunal mucosa in vitro and kidney in vivo was investigated in a 3 yr old patient with congenital glucose-galactose malabsorption, her family, and 16 normal volunteers. Glucose transport by normal human jejunal mucosa was concentrative, saturable, sodium and energy dependent, and exhibited competitive inhibition. Biopsy specimens from six normal controls and an asymptomatic...

Congenital glucose galactose malabsorption.

Introduction Congenital glucose galactose malabsorption (CGGM) is a rare autosomal recessive disorder, which presents as a protracted diarrhoea in early neonatal life. It is due to a defect in sodium coupled transport of glucose and galac­ tose in the enterocyte (1). Diarrhoea in CGGM is osmotic, caused by accumulation of unabsorbed glucose and ga­ lactose in the intestine (2), which results in...

Glucose-galactose malabsorption.

A Case Report of Glucose-Galactose Malabsorption in Iranian Child

Introduction Glucose-Galactose Malabsorption (GGM) is an autosomal recessive and rare disorder of intestinal transport of glucose and sodium-glucose cotransporter type (SGLT1). Case Report Our patient is a 32-day-old boy who was examined for severe diarrhea and acidosis and was treated with GGMdiagnosis. A number of laboratory tests were performed on this patient as well as positive test for r...

Genetic Disorders of Membrane Transport I. Glucose Galactose Malabsorption

Wright, Ernest M. Genetic Disorders of Membrane Transport. I. Glucose Galactose Malabsorption. Am. J. Physiol. 275 (Gastrointest. Liver Physiol. 38): G879–G882, 1998.—Glucose Galactose Malabsorption is a genetic disorder caused by a defect in glucose and galactose transport across the intestinal brush border. Normally, lactose in milk is broken down into glucose and galactose by lactase, an ect...